METHOD AND DEVICE FOR PERFORMING OPERATIONS AT CHARGED MICROLOCATIONS

摘要

Methods and devices are provided for producing dense arrays of chemical entities. A substrate comprises a plurality of microlocations having microelectrodes connected to a network for connection to a computer to control the voltage and polarity at each of said microelectrodes. Means for producing electrically charged microparticles comprising at least one chemical moiety produce a mist of the particles which is directed to the surface of said substrate, where the microparticles are captured by microlocations of lower potential. By providing chemical moieties concurrently or sequentially, oligomers may be formed or small organic compounds synthesized. The resulting arrays may be used for screening samples for specific binding entities.