发明名称 |
POLYMORPHS OF N-METHYL-N-(3-{3-[2-THIENYLCARBONYL]-PYRAZOL-[1,5- alpha ]-PYRIMIDIN-7-YL}PHENYL)ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO |
摘要 |
Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5- alpha ]-pyrimidin-7-yl}phenyl)acetamide (Compound (1)), and use of the same as a sedative-hypnotic, anxiolytic, anticonvulsant, and skeletal muscle relaxant agent. Processes for making the same, as well as related compositions and methods are also disclosed, particularly with regard to treatment of insomnia. A polymorph Form I possessing exception physical and heat stability is provided. A polymorph Form II.
|
申请公布号 |
WO0115700(A1) |
申请公布日期 |
2001.03.08 |
申请号 |
WO2000US24051 |
申请日期 |
2000.09.01 |
申请人 |
NEUROCRINE BIOSCIENCES, INC.;THIELE, WILLIAM, J.;O'DONNELL, PATRICK, B. |
发明人 |
THIELE, WILLIAM, J.;O'DONNELL, PATRICK, B. |
分类号 |
A61K9/20;A61K9/48;A61K31/505;A61K31/519;A61P21/02;A61P25/08;A61P25/20;A61P25/22;C07D487/02;C07D487/04;(IPC1-7):A61K31/519 |
主分类号 |
A61K9/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|