CRYSTAL STRUCTURES OF DOMAINS OF RECEPTOR PROTEIN TYROSINE KINASES AND THEIR LIGANDS
摘要
The determination and use of three dimensional structures of receptor protein tyrosine kinases and/or their ligands are described. One particular group of such structures includes three dimensional structures of the extracellular domain of RPTKs. The three dimensional structures of RPTKs can faciliate the design and identification of modulators of RPTK function. Other such structures can include of RPTK ligands, such as stem cell factor or a fragment thereof. Modulators of RPTK function can be used to treat diseases that are mediated by inappropriate RPTK activity.
申请公布号
WO0116181(A2)
申请公布日期
2001.03.08
申请号
WO2000US23744
申请日期
2000.08.30
申请人
NEW YORK UNIVERSITY SCHOOL OF MEDICINE;SCHLESSINGER, JOSEPH;HUBBARD, STEVAN, B.;MOHAMMADI, MOOSA