| 摘要 |
The use of an enzyme found in fungi, bacteria, insects, nematodes, worms, mites, protozoa etc. as a target in a screening assay is described by means of which agents capable of inhibiting the function of that enzyme may be identified. The screening assay may include complete cell or purified-enzyme assays. In particular, the present invention relates to a screening assay for inhibitors or suppressors of sugar alcohol phosphatases or sugar phosphatases, and more in particular inhibitors or suppressors of trehalose-6-phosphate phosphatase, as well as preparations, in particular, pharmaceutical preparations, which include inhibitors or suppressors obtained from the screening assay. Inhibitors are described as well as applications in biocides and antifungal pharmaceuticals. |
