发明名称 |
PHARMACEUTICAL COMBINATION OF ETHINYLESTRADIOL AND DROSPIRENONE FOR USE AS A CONTRACEPTIVE |
摘要 |
A pharmaceutical composition comprises, as a first active agent, 6 beta , 7 beta ; 15 beta , 16 beta -dimethylene-3-oxo-17 alpha -pregn-4-ene-21,17-carbolactone (drospirenone) in an amount corresponding to a daily dosage, on administration of the composition, of from about 2 mg to about 4 mg, and, as a second active agent, 17 alpha -ethinylestradiol (ethinylestradiol) in an amount corresponding to a daily dosage of from about 0.01 mg to about 0.05 mg, together with one or more pharmaceutically acceptable carriers or excipients. In a specific embodiment, the composition consists of a number of separately packaged and individually removable daily dosage units placed in a packaging unit and intended for oral administration for a period of at least 21 consecutive days, wherein said daily dosage units comprise the combination of drospirenone and ethinylestradiol. The composition may further comprise 7 or less daily dosage units containing no active agent or containing ethinylestradiol alone.
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申请公布号 |
WO0115701(A1) |
申请公布日期 |
2001.03.08 |
申请号 |
WO2000IB01213 |
申请日期 |
2000.08.31 |
申请人 |
SCHERING AKTIENGESELLSCHAFT;HEIL, WOLFGANG;HILMAN, JUERGEN;LIPP, RALPH;HEITHECKER, RENATE |
发明人 |
HEIL, WOLFGANG;HILMAN, JUERGEN;LIPP, RALPH;HEITHECKER, RENATE |
分类号 |
A61K9/14;A61K;A61K9/20;A61K9/28;A61K31/565;A61K31/567;A61K31/569;A61K31/57;A61K31/58;A61K31/585;A61P;A61P5/28;A61P15/00;A61P15/18;(IPC1-7):A61K31/565 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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