| 摘要 |
The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, usi ng a light source that preferably transmits light to a treatment site transcutaneously. The method provides for administering to the subject a therapeutically effective amount of a photosensitizing agent. This photosensitizing agent preferentially associates with the target tissue. Lig ht at a wavelength or waveband corresponding to that which is absorbed by the photosensitizing agent is then administered. The light intensity is relative ly low, but a high total fluence is employed to ensure the activation of the photosensitizing agent. Transcutaneous PDT is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, t he abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease. |
