发明名称 |
4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
摘要 |
Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha<SUB>2B </SUB>and/or alpha<SUB>2C </SUB>adrenergic receptors in preference over alpha<SUB>2A </SUB>adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and/or alleviations of conditions which are responsive to treatment by agonists of alpha<SUB>2B </SUB>adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.
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申请公布号 |
US7345077(B2) |
申请公布日期 |
2008.03.18 |
申请号 |
US20050143334 |
申请日期 |
2005.06.02 |
申请人 |
ALLERGAN, INC. |
发明人 |
CHOW KEN;HEIDELBAUGH TODD;GIL DANIEL;GARST MICHAEL;WHEELER LARRY A.;NGUYEN PHONG X.;GOMEZ DARIO G. |
分类号 |
A61K31/4164;A61K31/4166;A61K31/4178;A61K31/4709;A61P1/04;A61P1/12;A61P9/02;A61P9/04;A61P9/12;A61P13/02;A61P19/02;A61P19/06;A61P21/02;A61P25/00;A61P25/02;A61P25/04;A61P25/22;A61P25/24;A61P25/28;A61P27/06;A61P27/16;A61P37/06;C07D233/30;C07D233/70;C07D233/84;C07D401/06;C07D405/06;C07D409/06;C07D409/08 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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