The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the invention are capable of selective targeting due to the use of tumor-specific and/or cell-specific promoters to drive expression of the herpes gamma 34.5 gene.
申请公布号
WO0116331(A1)
申请公布日期
2001.03.08
申请号
WO2000US02409
申请日期
2000.02.02
申请人
THE GENERAL HOSPITAL CORPORATION;CHIOCCA, E., ANTONIO;CHUNG, RICHARD, Y.