METHODS FOR ASSAYING MITOCHONDRIAL INTERMEMBRANE SPACE PROTEIN TRANSLOCATION
摘要
Compositions and methods are provided for identifying agents that alter mitochondrial intermembrane space protein (MISP) translocation. The screening methods generally detect agents that alter the level of detectable extramitochondrial MISP following exposure of a cell to an agent known or suspected to induce mitochondrial intermembrane space protein translocation. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.
申请公布号
WO0116373(A2)
申请公布日期
2001.03.08
申请号
WO2000US23638
申请日期
2000.08.28
申请人
MITOKOR;MURPHY, ANNE, N.;WILEY, SANDRA, EILEEN;ANDREYEV, ALEXANDER, Y.
发明人
MURPHY, ANNE, N.;WILEY, SANDRA, EILEEN;ANDREYEV, ALEXANDER, Y.