CINNAMIC ACID NITRILE METHOD OF PRODUCTION AND USE THEREOF

摘要

The invention relates to substituted cinnamic acid nitriles of the formula (I) wherein X = CN, COOR<4>, CONR<5>R<6>, COaryl, COalkyl, aryl, heteroaryl, R<1> = H, alkyl, arylalkyl, [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl, R<2> and R<3> = independent of each other H, hydroxy, alkoxy, benzyl, R<4> = H, alkyl, [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl, R<5> = H, alkyl, alkoxyalkyl, alkoxy-oxoalkyl, diakylaminoalkyl, amino-oxoalkyl, aryl, arylalkyl, [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl, morpholinoalkyl, furanyalkyl, thienylalkyl, R<6> = H, alkyl, or NR<5>R<6> together = cyclic amines such as pyrrolidine, morpholine, piperidine, subst. piperazine, whereby at least one of the radicals R<1>, R<4> or R<5> is a [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl-radical, in addition to the addition thereof with pharmacologically compatible acids. The compounds are active as prophylactic and therapeutic medicaments for the treatment of benign prostatahyperplasia. A method for the production of cinnamic acid nitrile is also disclosed; an appropriately substituted benzaldehyde is reacted with a substituted acetonitrile in a Knoevenagel-condensation reaction.