发明名称 |
SCREENING FOR AGENTS MODULATING TGF-BETA CELL SIGNALING |
摘要 |
Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF-.beta.) and members of the TGF-.beta . family, such as bone morphogenic protein (BMP). Such agents may be identifie d using screens that evaluate candidate agents for the ability to modulate Sma d protein degradation. Agents identified as described herein may be used to augment or inhibit signaling mediated by one or more TGF-.beta. family membe rs in a variety of cell types and for therapeutic purposes.
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申请公布号 |
CA2383514(A1) |
申请公布日期 |
2001.03.08 |
申请号 |
CA20002383514 |
申请日期 |
2000.08.29 |
申请人 |
SIGNAL PHARMACEUTICALS, INC. |
发明人 |
HOEKSTRA, MERL F.;XIE, WEILIN;MERCURIO, FRANK M.;MURRAY, BRION W. |
分类号 |
G01N33/50;A61K45/00;A61P29/00;A61P35/00;A61P43/00;C12Q1/25;G01N33/15;G01N33/543;G01N33/566;G01N33/58;G01N33/74;(IPC1-7):G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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