发明名称 SCREENING FOR AGENTS MODULATING TGF-BETA CELL SIGNALING
摘要 Methods are provided for identifying agents that modulate signaling mediated by transforming growth factor beta (TGF-.beta.) and members of the TGF-.beta . family, such as bone morphogenic protein (BMP). Such agents may be identifie d using screens that evaluate candidate agents for the ability to modulate Sma d protein degradation. Agents identified as described herein may be used to augment or inhibit signaling mediated by one or more TGF-.beta. family membe rs in a variety of cell types and for therapeutic purposes.
申请公布号 CA2383514(A1) 申请公布日期 2001.03.08
申请号 CA20002383514 申请日期 2000.08.29
申请人 SIGNAL PHARMACEUTICALS, INC. 发明人 HOEKSTRA, MERL F.;XIE, WEILIN;MERCURIO, FRANK M.;MURRAY, BRION W.
分类号 G01N33/50;A61K45/00;A61P29/00;A61P35/00;A61P43/00;C12Q1/25;G01N33/15;G01N33/543;G01N33/566;G01N33/58;G01N33/74;(IPC1-7):G01N33/68 主分类号 G01N33/50
代理机构 代理人
主权项
地址