HYDROXAMIC ACID DERIVATIVES AND MEDICINAL UTILIZATION THEREOF

摘要

<CHEM> Hydroxamic acid derivatives represented by general formula (I) or pharmacologically acceptable salts thereof; medicinal compositions containing the same and medicinal utilization thereof wherein each symbol has the meaning as defined in the specification. Because of having TNF- alpha production inhibitory effect, these derivatives or pharmacologically acceptable salts thereof are useful in preventing/treating autoimmune diseases and inflammatory diseases, for example, sepsis, MOF, rheumatoid arthritis, Crohn's disease, cachexia, myasthenia gravis, systemic lupus erythematosus, asthma, I type diabetes and psoriasis.