| 发明名称 |
DNA molecules stabilized by modifications of the 3'-terminal phosphodiester linkage |
| 摘要 |
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
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| 申请公布号 |
US6197944(B1) |
申请公布日期 |
2001.03.06 |
| 申请号 |
US19940268381 |
申请日期 |
1994.06.29 |
| 申请人 |
INTEGRATED DNA TECHNOLOGIES, INC. |
发明人 |
WALDER JOSEPH A.;WALDER ROXANNE Y.;EDER PAUL S.;DAGLE JOHN M. |
| 分类号 |
C12N15/09;A61K48/00;C07H19/00;C07H21/00;C12N15/113;C12Q1/68;(IPC1-7):C07H19/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
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