发明名称 |
Taste masked liquid suspensions |
摘要 |
The present invention relates to a taste-masked pharmaceutical composition. In particular the invention relates to suspensions of microcapsules taste-masked as a function of a polymer coating and the pH of a suspending medium. Surprisingly, a polymer considered permeable maintains taste masking in this media whereas a polymer considered impervious by the industry does not. There is provided a taste masked oral pharmaceutical composition including: a pharmaceutically active ingredient having a pH-dependent solubility; a polymer encapsulating said pharmaceutically active ingredient, said polymer having a quaternary ammonium functionality; a suspending medium for suspending the encapsulated pharmaceutically active ingredient, said medium adjusted to a predetermined pH at which the pharmaceutically active ingredient remains substantially insoluble; and wherein the pharmaceutically active ingredient is taste masked by the combination of the polymer and suspending medium.
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申请公布号 |
US6197348(B1) |
申请公布日期 |
2001.03.06 |
申请号 |
US19990180354 |
申请日期 |
1999.02.25 |
申请人 |
F H FAULDING & CO., LIMITED |
发明人 |
MORELLA ANGELO MARIO;PITMAN IAN HAMILTON;HEINICKE GRANT WAYNE |
分类号 |
A61K9/107;A61K9/00;A61K9/16;A61K9/20;A61K9/48;A61K9/50;A61K31/19;A61K31/192;A61K31/195;A61K31/196;A61K31/405;A61K31/44;A61K31/4427;A61K31/4439;A61K31/505;A61K31/519;A61K31/529;A61K31/70;A61K31/7042;A61K31/7048;A61K47/32;A61K47/38;(IPC1-7):A61K9/02 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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