AROMATIC KETONES SUITABLE FOR THE TREATMENT OF DISEASES ACCOMPANIED BY ABNORMAL ANGIOGENESIS

摘要

The present invention provides a novel bioactive substance having an antiangiogenic effect. The chemical compound represented by the formula (1): <CHEM> (wherein, R<1> represents hydrogen atom, aldehyde group or a lower acyl group, R<2> and R<3> are the same as or different from each other and represent hydrogen atom or a lower alkoxy group or are combined to represent oxygen atom, R<4> represents a lower alkyl group and R<5> represents hydrogen atom or a lower alkyl group, provided that compounds in which R<1> is aldehyde group, R<2> and R<3> are different from each other and are hydrogen atom or methoxy group, R<4> is ethyl group and R<5> is hydrogen atom are excluded), a salt thereof or a hydrate thereof was isolated from the culture broth of genus Streptomyces and the structure thereof was analyzed. <IMAGE>