| 摘要 |
Reflectors such as microbubbles in a contrast agent introduced into a blood vessel of a patient are destroyed (or otherwise acoustically altered) using focused ultrasound at a modulation point according to an input modulation sequence. This creates "gaps" in the flowing contrast agent that are sensed at a downstream sensing point. The pattern of gaps is then matched in time with the input modulation sequence to determine a transit time for the gaps, which is also the flow velocity of the blood. The input modulation sequence creates at least two gaps, but may otherwise have any of several different forms, which include, among others, square-wave, maximal sequence, random binary patterns. Edge-detection and correlation techniques are used to match the input and sensed gap patterns. By triggering the input sequence off of a heart rate monitor, a flow velocity profile may also be calculated and displayed from one heart beat to the next. By also imaging the blood vessel and determining its cross-sectional area at at least one point, the invention is also able to provide a volumetric blood flow estimate.
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