| 摘要 |
Long-term usage of AICAR (5-amino, 4-imidazole carboxamide riboside) has been found to decrease in mammals atherosclerosis and increase insulin sensitivity, resulting in benefits in diseases such as diabetes, hypertension, and gallstones. In addition, long-term usage of AICAR has an impact on amount of food consumed and results in reduced fat build-up and increase in muscle mass. AICAR appears useful to prevent vascular diseases associated with hyperglycemia, high plasma levels of free fatty acids (FFA) and insulin resistance by administering an agent that activates fatty acid oxidation. Thus, AICAR appears to be useful both for treatment and prevention of vascular diseases. Animal tests have shown that that chronic treatment with AICAR has not resulted in any noticeable toxic effects. |
