发明名称 |
Anti-inflammatory actions of cytochrome p450 epoxygenase-derived eicosanoids |
摘要 |
Epoxyeicosatrienoic acids (EETs) are products of cytocrome P450 epoxygenases that have vasodilatory properties similar to endotheilum-derived hyperpolarizing factor (EDHF). The cytochrome P450 isoform CYP2J2 was cloned and identified as a source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytolcine-induced endothelial cell adhesion molecule expression and prevented subsequent leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-kappaB and IkappaB kinase (IKK). The inhibitory effects of EETs were independent of their membrane hyporpolarizing effects suggesting that these molecules play an important non-vasodilatory role in vascular inflammation. |
申请公布号 |
AU6534100(A) |
申请公布日期 |
2001.03.05 |
申请号 |
AU20000065341 |
申请日期 |
2000.08.10 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;NATIONAL INSTITUTES OF HEALTH |
发明人 |
JAMES K. LIAO;DARRYL ZELDIN |
分类号 |
A61K31/16;A61K31/17;A61K31/202;A61K31/325;A61K31/557;A61K31/558;A61K38/44;A61K45/06;A61K48/00;C12Q1/26 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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