| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention refers to 1,2,4,5-tetrasubstituted imidazole derivatives of general formula (I) , where R1 represents chlorine, bromine, fluorine or hydrogen atom, R2 represents chlorine or bromine atom, A represents nitrogen atom or group CH, X represents sulphur atom or sulphoxide (S=O) group, or sulphonic (SO2) group, Y represents hydrogen atom or methyl, ethyl, n-propyl, isopropyl, n-butyl, tert-butyl group, Z represents CH group, n represents number 1,2 or 3, and pharmacologically acceptable salts of compounds. Besides, the invention concerns a pharmaceutical composition based on the compound of general formula (I), to the compounds of general formulas and and to application of compounds of general formula (I). ^ EFFECT: new imidazole derivatives being selective modulators of cannabinoid receptors CB1 with high selectivity. ^ 12 cl, 1 tbl, 4 ex |
