发明名称 PROCEDE DE DETECTION DE L'EXPRESSION D'UNE PROTEINE D'ENVELOPPE D'UN RETROVIRUS ENDOGENE HUMAIN ET UTILISATIONS D'UN GENE CODANT POUR CETTE PROTEINE
摘要 The invention concerns a method for detecting the expression of an envelope protein or polypeptide of a human endogenous retrovirus, characterised in that the protein or polypeptide has a polypeptide sequence comprising the sequence SEQ ID NO: 1 or a fragment of SEQ ID NO: 1 or a sequence having, for every sequence of 20 amino acids, at least 90 % identity with the SEQ ID NO: 1 or with a fragment of SEQ ID NO: 1, and the method consists in detecting the fusogenic power of said protein or said fragment in the cells of a cell tissue or cell culture, by demonstrating the formation of syncytia. A gene or a nucleic acid or a fragment thereof is used for preparing a therapeutic or prophylactic composition, in particular for treating cancers and for preventing deficiency in placental development.
申请公布号 FR2797889(A1) 申请公布日期 2001.03.02
申请号 FR19990011793 申请日期 1999.09.15
申请人 BIO MERIEUX 发明人 LAVILLETTE DIMITRI;BOUTON OLIVIER;RUGGIERI ALESSIA;MALLET FRANCOIS;COSSET FRANCOIS LOIC;BLOND JEAN LUC
分类号 C12N15/09;A61K31/7088;A61K35/76;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P15/00;A61P35/00;C07K14/15;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/48;C12Q1/02;(IPC1-7):C12N15/48;C12N15/63;A61K31/708 主分类号 C12N15/09
代理机构 代理人
主权项
地址