发明名称 |
FORMULATION FOR SPRAY-DRYING LARGE POROUS PARTICLES |
摘要 |
Particles having a tap density less than about 0.4 g/cm<3> are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophAtidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.
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申请公布号 |
WO0113892(A2) |
申请公布日期 |
2001.03.01 |
申请号 |
WO2000US23118 |
申请日期 |
2000.08.23 |
申请人 |
ADVANCED INHALATION RESEARCH, INC.;LIPP, MICHAEL, M.;BATYCKY, RICHARD, P.;CAPONETTI, GIOVANNI |
发明人 |
LIPP, MICHAEL, M.;BATYCKY, RICHARD, P.;CAPONETTI, GIOVANNI |
分类号 |
A61K9/14;A61K9/00;A61K9/16;A61K31/137;A61K45/00;A61K47/04;A61K47/12;A61K47/24;A61K49/00;A61P11/00;(IPC1-7):A61K9/16;A61K9/72 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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