发明名称 |
METHODS OF OBTAINING 2-METHOXYESTRADIOL OF HIGH PURITY |
摘要 |
2-methoxyestradiol having greater than 98% purity is obtained by synthetic o r purification methods. This highly pure 2-methoxy estradiol, lacking estrogen ic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a n on- polar solvent, such as chloroform, and a polar solvent, such as methanol.</S DOAB>
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申请公布号 |
CA2376297(A1) |
申请公布日期 |
2001.03.01 |
申请号 |
CA20002376297 |
申请日期 |
2000.08.23 |
申请人 |
ENTREMED, INC. |
发明人 |
TRESTON, ANTHONY M.;AGOSTON, GREGORY E.;SHAH, JAMSHED H. |
分类号 |
A61K31/565;A61P9/00;A61P9/10;A61P15/00;A61P15/08;A61P17/02;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C07B61/00;C07J1/00;(IPC1-7):C07J1/00 |
主分类号 |
A61K31/565 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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