| 摘要 |
<p>A method for proliferating a hepatitis virus such as HCV and an apparatus therefor. A method of proliferating cells (for example, hepatocytes), which are less adhesive to a carrier, in a large amount over a long time. More particularly, the above method comprises infecting hepatocytes, which are maintained in a radial flow type hepatocyte bioreactor consisting of a main bioreactor unit containing the hepatocytes carried on a particulate porous carrier and a liquid culture medium flown from the periphery of the main bioreactor unit toward the center thereof, with a hepatitis virus; continuously flowing the liquid culture medium from the periphery of the main bioreactor unit toward the center thereof; and thus proliferating the hepatitis virus in the hepatocytes thus infected.</p> |
