发明名称 |
HDAC4 AND HDAC5 IN THE REGULATION OF CARDIAC GENE EXPRESSION |
摘要 |
The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation t o cardiac hypertrophy. More specifically, the present invention shows that Ca2 + stimulation of the hypertrophic response is mediated through an HDAC 4 and 5 interaction with MEF2, and that phosphorylation of HDACs results in loss of HDAC-mediated repression of MEF2 hypertrophic action. Thus, the present invention provides methods and compositions of treating cardiac hypertrophy, as well as methods and compositions for identifying subjects at risk for cardiac hypertrophy. Further provided are methods for the detection of compounds having therapeutic activity toward cardiac hypertrophy.
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申请公布号 |
CA2382045(A1) |
申请公布日期 |
2001.03.01 |
申请号 |
CA20002382045 |
申请日期 |
2000.08.21 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
MCKINSEY, TIMOTHY A.;LU, JIANRONG;OLSON, ERIC N. |
分类号 |
A01K67/027;A61K35/76;A61K38/43;A61K45/00;A61K48/00;A61P9/00;C12N15/09;C12Q1/44;C12Q1/48;C12Q1/54;C12Q1/66;G01N33/15;G01N33/50;G01N33/68;(IPC1-7):C12Q1/44;A61K38/46 |
主分类号 |
A01K67/027 |
代理机构 |
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