摘要 |
The invention provides isolated nucleic acid molecules, designated ABCB12 transporter nucleic acid molecules, which encode novel ABC transporter famil y members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCB12 transported nucleic acid molecules, host cells into which the expression vectors have been introduced , and nonhuman transgenic animals in which an ABCB12 transported gene has been introduced or disrupted. The invention still further provides isolated ABCB1 2 transporter proteins, fusion proteins, antigenic peptides, anti-ABCB12 transporter antibodies, and screening assays for ABCB12 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
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