摘要 |
A method for predicting the clinical outcome for a patient after the patient has received therapy for an acute coronary syndrome such as myocardial infarction comprises: (a) optionally, but preferably, detecting a first variable comprising a serum creatine kinase-MB release curve area in the patient after initiation of said therapy; (b) detecting a second variable comprising a serum creatine kinase-MB release curve maxima in the patient after initiation of said therapy; then (c) optionally, but preferably, detecting a third variable comprising the slope of the descending portion of the serum creatine kinase-MB release curve after initiation of said therapy (wherein a steep slope for said descending portion is a more favorable indicator of clinical outcome than a shallow slope); and (d) generating a prediction of clinical outcome for said patient from the variables collected above. The method is useful in conjunction with established therapies such as thrombolytic therapy, and is particularly useful as a surrogate end point in clinical trials of new potential therapies.
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申请人 |
DUKE UNIVERSITY;CHRISTENSON, ROBERT, H.;DUH, SHOW-HONG;VOLLMER, ROBIN, T.;OHMAN, E., MAGNUS;THOMPSON, TREVOR, D.;NEWBY, L., KIRSTIN;CALIFF, ROBERT, M. |
发明人 |
CHRISTENSON, ROBERT, H.;DUH, SHOW-HONG;VOLLMER, ROBIN, T.;OHMAN, E., MAGNUS;THOMPSON, TREVOR, D.;NEWBY, L., KIRSTIN;CALIFF, ROBERT, M. |