PROCESS FOR PRODUCING FINE MEDICINAL SUBSTANCES

摘要

The method of producing fine medicament particles suitable for inhalation, particles produced by the method and apparatus suitable for carrying out the method is claimed. The method comprises contacting a stream or streams of a solution of medicament with a stream or streams of a liquid in which the medicament is insoluble in a confined chamber such that a region of intense turbulence and mixing is formed. The medicament crystallises as fine particl es with minimal inclusion of solvent or anti-solvent impurities. The crystallis ed medicament is separated from suspension by standard techniques. Careful control of relative stream velocity, solution concentration and proportion o f solution and anti-solvent in the streams ensures a uniform product.