发明名称 |
METHOD FOR COUPLING, IN SOLUTION, A PEPTIDE WITH AT LEAST ANOTHER COMPOUND AND USES THEREOF |
摘要 |
The invention concerns a method for coupling a peptide with at least a compound A, of the non-peptide type, bearing a function selected among the group consisting of carboxylic acid functions and alcohol functions. The invention is characterised in that said coupling comprises a step which consists in producing, in solution, a hydrazide bond between said peptide and said compound A. The invention also concerns modified peptides essentially formed by a peptide bound by a hydrazide bond to at least a compound A as defined above, such as a lipid, a sugar, an alcohol or a fluorescent marker, as well as the uses of said modified peptides. The invention further concerns the use of N,N'-tri(Boc)hydrazinoacetic and N,N'-di(Boc)hydrazinoacetic acids to functionalize a peptide with a alpha -hydrazinoacetic group.
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申请公布号 |
WO0114408(A2) |
申请公布日期 |
2001.03.01 |
申请号 |
WO2000FR02336 |
申请日期 |
2000.08.18 |
申请人 |
INSTITUT PASTEUR DE LILLE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;BONNET, DOMINIQUE;MELNYK, OLEG;GRAS-MASSE, HELENE |
发明人 |
BONNET, DOMINIQUE;MELNYK, OLEG;GRAS-MASSE, HELENE |
分类号 |
A61K39/385;A61K39/00;A61P37/04;C07K1/00;C07K1/10;C07K1/107;C07K1/20;C07K7/02;C07K7/06;C07K7/08;C07K14/00;(IPC1-7):C07K1/00 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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