IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

摘要

A class of substituted imidazo[1,2-d][1,2,4]triazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at th e 8-position, a substituted alkoxy moiety at the 2-position, a range of substituents at the 3-position and an optional alkyl or cycloalkyl substitue nt at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and a re accordingly of benefit in the treatment and/or prevention of disorders of th e central nervous system, including anxiety and convulsions.