发明名称 |
TRIAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND /OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS |
摘要 |
Compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds. |
申请公布号 |
CA2707422(C) |
申请公布日期 |
2016.06.07 |
申请号 |
CA20082707422 |
申请日期 |
2008.12.08 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CHEN, LI;DILLON, MICHAEL PATRICK;FENG, LICHUN;HAWLEY, RONALD CHARLES;YANG, MINMIN |
分类号 |
C07D249/06;A61K31/4192;A61K31/497;A61P11/00;A61P13/02;A61P29/00;C07D403/12;C07D403/14 |
主分类号 |
C07D249/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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