METHOD OF PRODUCING OPTICALLY ACTIVE ß-AMINOCARBONYL COMPOUND

摘要

In a method of producing an optically active β-aminocarbonyl compound using a column reactor, a column for a column reactor is charged with asymmetric catalyst particles to form a column reactor. Compounds for a Mannich-type reaction are introduced into the column reactor to be brought into contact with the asymmetric catalyst particles, to thereby convert the compounds to an optically active β-aminocarbonyl compound. The preferable asymmetric catalyst particles are resin particles that are prepared from a monomer composition containing a proline derivative monomer having an unsaturated bond and a radical polymerization initiator, and that act as a catalyst for an asymmetric Mannich-type reaction.

主权项

1. A method of producing an optically active β-aminocarbonyl compound by an asymmetric Mannich-type reaction using a column reactor in which a column is charged with asymmetric catalyst particles, wherein
the asymmetric catalyst particles are resin particles prepared from a monomer composition containing a monomer having an asymmetric source, andthe method comprises introducing compounds for a Mannich-type reaction into the column reactor to bring the compounds into contact with the asymmetric catalyst particles, to thereby convert the compounds for a Mannich-type reaction to an optically active β-aminocarbonyl compound.