Influenza vaccine containing pertussis toxin

摘要

The invention provides a vaccine composition comprising an effective immunogenic amount of an influenza antigen and an effective adjuvant amount of a non-toxic mutant form of pertussis toxin. The influenza antigen preferably comprises haemagglutinin and neuraminidase antigens, and in particular purified haemagglutinin and neuraminidase antigens. The non-toxic mutant form of pertussis toxin may be one in which the Glu 129 amino acid in the S1 sub-unit has been substituted by another amino acid, for example by glycine, and the arginine 9 amino acid residue has been substituted by another amino acid, for example by lysine.