发明名称 |
Inhibitors of metazoan parasite proteases |
摘要 |
Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula Iwherein A is a substituted or unsubstituted heteroaromatic ring system comprising one to three rings which binds to at least one of the S2, S1 and S1' subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which binds to at least one of the S1', S1 and S2 subsites; and X is -C=C-C(=O)-. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria and other infectious diseases.
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申请公布号 |
US6194421(B1) |
申请公布日期 |
2001.02.27 |
申请号 |
US19970000801 |
申请日期 |
1997.12.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
COHEN FRED E.;MCKERROW JAMES H.;KENYON GEORGE L.;LI ZHE;CHEN XIAOWU;GONG BAOQING;LI RONGSHI |
分类号 |
A61K31/12;A61K31/135;A61K31/136;A61K31/165;A61K31/17;A61K31/195;A61K31/34;A61K31/35;A61K31/36;A61K31/365;A61K31/40;A61K31/415;A61K31/4164;A61K31/4178;A61K31/44;A61K31/4402;A61K31/4406;A61K31/47;A61K31/472;A61K31/50;A61K31/505;A61K31/60;A61P33/02;A61P33/06;A61P33/12;(IPC1-7):A61K31/404;A61K31/502 |
主分类号 |
A61K31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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