发明名称 |
Method for modulating inflammatory response comprising administering morphogen |
摘要 |
The invention provides methods for alleviating immune cell mediated inflammatory responses to injury to mammalian tissue. The present methods make use of osteogenic protein 1(OP-1), which is appreciated herein as tissue morphogen, i.e., a substance competent to induce tissue-specific morphogenesis of mammalian body tissues in addition to bone and/or cartilage. Alternatively, the present methods make use of other naturally-occurring or biosynthetic proteins sharing a defined structural and functional relationship with OP-1 and thus appreciated herein also to be tissue morphogens. The invention is particularly adapted to alleviating tissue damage associated with ischemia-reperfusion injury or hyperoxia injury in mammals, including humans.
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申请公布号 |
US6194376(B1) |
申请公布日期 |
2001.02.27 |
申请号 |
US19950414033 |
申请日期 |
1995.03.30 |
申请人 |
CREATIVE BIOMOLECULES, INC. |
发明人 |
KUBERASAMPATH THANGAVEL;PANG ROY H. L.;OPPERMANN HERMANN;RUEGER DAVID C.;COHEN CHARLES M. |
分类号 |
A01N1/02;A61F2/00;A61K6/00;A61K38/17;A61K38/18;A61L27/22;A61L27/24;C07K14/495;C07K14/51;C07K16/22;(IPC1-7):A61K38/18 |
主分类号 |
A01N1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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