| 摘要 |
This invention provides a compound of the formula: (see fig. I ) and its pharmaceutically acceptable salts, wherein Ar1 is selected from groups of the following formulae: (see fig. II), (see fig.III), (see fig. IV) and (see fig, V) ; wherein, R1 and R2 are independently hydrogen or C1-C6 alkyl; W is (CH2)n wherein n is from 1 to 3, or -CH=CH-; X is C1-C6 alkoxy or halo C1-C6 alkoxy; and Ar2 is phenyl optionally substituted by halogen atom. These compounds are useful in the treatment of a gastrointestinal disorder, a central nervous system (CNS) disorder, an inflammatory disease, emesis, urinary incontinence, pain, migraine, sunburn, angiogenesis, diseases, disorders and adverse conditions caused by Helicobacter pylori, or the like in a mammalian subject, especially humans.
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