| 摘要 |
<p>organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of 5-naphthalene-1-yl-1,3-dioxane in the form of pure stereoisomer or the mixture of stereoisomers of the formula (I) where R1 means hydrogen atom or (C1-C4)-alkyl, (C3-C6)-cycloalkylmethyl or phenyl-(C1-C3)-alkyl group possibly substituted by phenyl ring with one or more atoms or group taken among halogen atoms and methyl, trifluoromethyl, methoxy- and cyano-groups; R2 means hydroxyl or (C1-C4)-alkoxy-group or the group of the general formula NR3R4 where each of R3 and R4 means independently each of other hydrogen atom, linear or possibly branched (C1-C4)-alkyl group, (C3-C6)-cycloalkylmethyl group, phenyl group, phenylmethyl group or pyridyl group; or, alternatively, R3 and R4 in common with nitrogen atom carrying their form pyrrolidine or piperidine ring; n = 1, 2 or 3 in the form of free base or salt obtained by acid addition and different methods of their synthesis also. These compounds show neuroprotective activity and anticonvulsant properties and can be used for preparing drug and pharmaceutical composition. EFFECT: new compounds indicated above, improved methods of synthesis, valuable medicinal properties. 9 cl, 1 tbl, 12 ex</p> |
