发明名称 |
NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWIS A |
摘要 |
The present invention provides compositions for the production of an antibody or functional fragment thereof directed against Sialyl-Lewisa (sLea). The compositions of the invention include polynucleotides encoding a heavy chain and/or a light chain variable domain that binds to sLea. The invention also provides an isolated antibody or functional fragment thereof and methods of treating or preventing a disease, such as cancer or tumor formation, wherein the antibody or functional fragment includes a variable heavy chain domain and a variable light chain domain that has an amino acid sequence provided herein. The invention further provides a conjugate of an antibody or functional fragment thereof conjugated or recombinantly fused to a diagnostic agent, detectable agent or therapeutic agent, and methods of treating, preventing or diagnosing a disease in a subject in need thereof. |
申请公布号 |
EP3041507(A2) |
申请公布日期 |
2016.07.13 |
申请号 |
EP20140852746 |
申请日期 |
2014.08.26 |
申请人 |
MABVAX THERAPEUTICS, INC. |
发明人 |
SAWADA, Ritsuko;SUN, Shu-Man;SCHOLZ, Wolfgang |
分类号 |
A61K39/395;C07K16/30;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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