Integrated miniaturized device for processing and NMR detection of liquid phase samples

摘要

A miniaturized total analysis system with an in-line NMR detection compartment and an NMR rf microcoil detector is described for use in liquid phase analysis. The device is formed by microfabrication of microstructures in novel support substrates. The NMR detector coil may be fabricated directly in the support body at the point of detection or, alternatively, may be formed as part of a modular structure that is insertable into the device at the point of detection. In addition, an integrated device for sample preparation and NMR detection is provided comprising the miniaturized total analysis system and a miniature magnet configured to accept the miniaturized total analysis system, wherein the device is capable of generating an NMR spectrum. The invention herein is used for the analysis of small and/or macromolecular and/or other solutes in the liquid phase.