| 摘要 |
1. A compound of the formula I wherein: a is 0, 1, 2 or 3; each R is independently hydrogen, halo, cyano, amino, halo(C1-C4)alkyl, di(C1-C4)alkylamino, azido, C1-C6 alkyl, carbamoyl, carbamoyloxy, carbamoylamino, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4alkylsulfinyl, C1-C4alkylsulfonyl, pyrrolidino, piperidino or morpholino; R<0> is hydrogen, halo, C1-C4 alkyl or C1-C4 alkoxy; R<1> is halo, cyano, hydroxy, methyl, ethyl, methoxy, ethoxy, methylthio, methylsulfinyl or methylsulfonyl; R<2> is hydrogen, amino or -NHC(O)( C1-C6 alkyl); R<3> is dimethylamino, C1-C10 alkyl, halo(C1-C6)alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, phenyl, substituted phenyl, naphthyl, thienyl, thiazolidinyl, furyl, pyrrolidino, piperidino, morpholino or a group of the formula R<4> and R<5> are independently hydrogen or C1-C4 alkyl; or a pharmaceutically acceptable salt thereof. 2. A compound according to claim 1 where: where: a is 0, 1 or 2; each R is independently hydrogen, halo, C1-C4 alkyl, C1-C4 alkoxy or di(C1-C4)alkylamino; R<0> is hydrogen; R<2> is amino; R<3> is dimethylamino, C1-C6 alkyl, halo(C1-C6)alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, thienyl, thiazolidinyl, pyrrolidino, piperidino or morpholino; R<4> is hydrogen, methyl or ethyl; R<5> is hydrogen, methyl or ethyl; or a pharmaceutically acceptable salt thereof. 3. A compound according to claim 2 where: a is 0 or 1; each R is independently hydrogen, fluoro, methyl, ethyl, methoxy, ethoxy, dimethylamino; R<0> is hydrogen; R<3> is dimethylamino, C1-C4 alkyl, C3-C7 cycloalkyl or pyrrolidino; or a pharmaceutically acceptable salt thereof. 4. A compound according to claim 3 which is: or a pharmaceutically acceptable salt thereof. 5. A pharmaceutical formulation comprising a compound of formula I, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, associated with one or more pharmaceutically acceptable carriers, diluents or excipients. 6. A compound of formula I, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, for use as a pharmaceutical. 7. A compound of formula I, or a pharmaceutically acceptable salt thereof, as claimed in any one of claims 1 to 4, for use as an antiviral. |
