DNA MILLICHIP

摘要

The present invention provides novel arrays of oligonucleotide probes immobilized on a solid support in the form of a chip (millichip), which can be used for rapid and inexpensive analysis of nucleic acids. The arrays can have a plurality of different oligonucleotide probes that can provide for whole genome gene expression analysis. The millichip can be used for analysis of both RNA and DNA.

主权项

1. An array of oligonucleotide probes immobilized on a solid support, the array comprising at least about 1,000 different oligonucleotide probes and no more than about 100,000 different oligonucleotide probes about 30 to about 100 nucleotides in length, wherein the oligonucleotide probes occupy separate known sites in the array, wherein the array has a density of at least about 500,000 oligonucleotide probes per 1 cm2 solid support surface, wherein the volume of the solid support is between about 0.125 mm3 and about 30 mm3.