发明名称 Cyanoguanidines as cell proliferation inhibitors
摘要 The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which formula R stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, C 1 -C 4 alkyl, alkoxy or alkyloxycarbonyl, nitro, amino or cyano and X stands for direct bonding, substitutedC 3 -C 7 cycloalkylene, divalent heterocyclic ring (with one or more nitrogen, oxygen or sulfur), arylene, oxygen, one or two sulfur or amino which can be substituted by hydrogen or C 1 -C 4 alkyl; and Q 1 and Q 2 stands for C 1 -C 10 divalent hydrocarbon radical which can be straight, branched, cyclic, saturated or unsaturated; and pharmaceutically acceptable, non- toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.
申请公布号 KR20010013149(A) 申请公布日期 2001.02.26
申请号 KR19997011132 申请日期 1998.05.15
申请人 LEO PHARM PROD LTD 发明人 HUNNECHE CHARLOTTE SCHOU;PETERSEN HANS JORGEN
分类号 H04B1/7113;A61K31/44;A61K31/4409;A61P17/06;A61P35/00;C07D213/75;(IPC1-7):H04B1/69 主分类号 H04B1/7113
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