发明名称 Cyanoguanidines as cell proliferation inhibitors
摘要 The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which formula R1stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, carboxy, C1-C4alkyl, alkoxy or alkoxycarbonyl, nitro, amino or cyano and Q stands for C 9-C20divalent hydrocarbon radical which can be saturated, straight or branched or Q stands for C4- C20divalent hydrocarbon radical which can be cyclic or unsaturated and X stands for oxygen, sulfur or nitrogen the latter optionally being substituted by hydrogen or C1- C4alkyl and R2stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, C1-C 4 alkyl or alkoxy, hydroxy, halogen, trifluoromethyl, cyano, carboxamido, sulfamoyl or nitro; and pharmaceutically acceptable, non- toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.
申请公布号 KR20010013158(A) 申请公布日期 2001.02.26
申请号 KR19997011141 申请日期 1998.05.15
申请人 LEO PHARM PROD LTD 发明人 OTTOSEN ERIK R
分类号 C07D213/74;A61K31/44;A61P17/06;A61P35/00;A61P43/00;C07D213/75;(IPC1-7):G06F17/60 主分类号 C07D213/74
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