| 摘要 |
Disclosed are compounds having general formula (A) wherein Ar represents phenyl, which may be unsubstituted or substituted by one, two or three substituents independently selected from Cl, Br, F, -OMe, NO2, CF3, C1-4lower alkyl, -NMe2, -NEt2, -SCH3, -NHCOCH3; 2-thienyl; 2-furyl; 3- pyridyl; 4-pyridyl or 3-indolyl, and R represents -OCH 2R 1, in which R1is selected from -CH=CMe 2, -CMe=CH2, -C= CH; with the proviso that where Ar represents phenyl, R is other than 3- methyl-2-butenyl. The compounds possess a valuable antiproliferation activity both on sensitive cancerous cells and on cells which are resistant to common chemotherapeutic drugs. |
