Structured coatings for implants and process for the preparation thereof

摘要

The invention relates to a method for producing a powder-filled ceramic coating made from a precursor ceramic compound (for example, a sol-gel), said coating having an advantageous surface roughness and wherein active ingredients may be eluted from the matrix or filler under physiological conditions and to an implant which can be produced according to the claimed method.

主权项

1. Process for preparing an implant with a particle-filled, metal oxide coating, the process comprising:
(a) providing a mixture of an organic solvent and an organometallic precursor, wherein the organic solvent and the organometallic precursor are present in the mixture in the form of a sol; (b) adding a particle-shaped filler having a particle size between 0.1 and 10 μm to the mixture of step (a) to produce a preparation, wherein the amount of the particle-shaped filler added does not exceed 15% by weight of the total weight of the mixture; (c) applying the preparation of step (b) to an implant to provide a coating on the implant; and (d) drying the coating applied, wherein steps (a)-(d) are performed one or more times, with each iteration of step (b) employing a different particle-shaped filler, a different concentration of the particle-shaped filler, or both, whereby an implant with a particle-filled, metal oxide coating is prepared having a surface Ra value of 0.01 to 10 μm, optionally 0.1 to 5 μm, and further optionally 0.2 to 1.5 μm.