发明名称 Cyanoamidines as cell proliferation inhibitors
摘要 The present invention relates to hitherto unknown compounds of formula (I), or their tautomeric forms, the attachment to the pyridine being in the 2-, 3- or 4-position, in which formula R1stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, amino, trifluoromethyl, nitro, cyano, carboxy, or alkyl, alkoxy, or alkoxycarbonyl, the C-content of which can be from 1 to 4; Q stands for C4-C9divalent hydrocarbon radical which can be straight, branched, saturated or unsaturated; X stands for methylene, oxygen, sulphur or nitrogen, and R stands for hydrogen or for one or more substituents which can be the same or different and are selected from the group consisting of: hydroxy, amino, halogen, trifluoromethyl, cyano, nitro, carboxy, carbamoyl, methylenedioxy, or alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 4; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.
申请公布号 KR20010013163(A) 申请公布日期 2001.02.26
申请号 KR19997011147 申请日期 1998.05.15
申请人 LEO PHARM PROD LTD 发明人 OTTOSEN ERIK RYTTER
分类号 A61K31/44;A61P17/06;A61P35/00;A61P43/00;C07D213/78;C07D213/81;(IPC1-7):H01J17/49 主分类号 A61K31/44
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