METHOD AND DEVICE FOR DETECTING ONE BASE SUBSTITUTION SNP AND POINT MUTATION OF GENE AND DETECTION CHIP

摘要

PROBLEM TO BE SOLVED: To detect and analyze a large quantity of one base substitution SNP and point mutation with high sensitivity with a plurality of sample DNAs as a target. SOLUTION: A sample DNA is filled into a space part S in a chip 2 for detecting one base substitution SNP and point mutation of a gene, where a number of gold electrodes 8 are formed on a bottom surface 7 of a closed space S and oligonucleotide 10 made of a different gene arrangement, is fixed to the gold electrode 8, and a common electrode 16 is arranged so that it does not touch the gold electrode 8, a voltage is applied between the common electrode 16 and the gold electrode 8, and a current is detected and a double-chain DNA subjected to hybridization is detected for analysis.