Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof

摘要

The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.

主权项

1. A filamentous fungal cell comprising at least one endogenous protease having reduced or no protease activity, and a recombinant polynucleotide encoding a heterologous polypeptide, wherein the cell has reduced or no protease activity in one or more the following proteases: amp2, mp1, mp2, mp3, mp4, mp5, pep9, amp1, and sep1.