| 摘要 |
PROBLEM TO BE SOLVED: To enhance sensitivity without sacrificing specificity of antigen- antibody reaction in clinical diagnosis by adding a morpholinoacrylamide or N-vinylacylamide polymer. SOLUTION: A buffer solution for diluting a specimen being used for assaying AFP with anti-human alphafetoprotein (AFP) sensitizing latex contains morpholinoacrylamide or polyvinylformamide. Sensitivity of assay is enhanced, because a morpholinoacrylamide or N-vinylacylamide polymer interacts between an antigen or an antibody on the surface of a sensitized particle and the corresponding antigen or antibody in a specimen to induce agglutination thus accelerating reaction between the antigen and the antibody. A morpholinoacrylamide or N-vinylacylamide polymer having molecular weight of 300,000-1000,000 is especially preferable.
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