| 发明名称 | ICMT inhibitors | ||
| 摘要 | The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CH2NR1R2 wherein R1 is H or C1 to C3 alkyl, R1 being optionally substituted with —OH, —SH, —NH2 or NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and R2 is C1 to C3 alkyl or (CH2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group. | ||
| 申请公布号 | US9422238(B2) | 申请公布日期 | 2016.08.23 |
| 申请号 | US201314404912 | 申请日期 | 2013.05.30 |
| 申请人 | National University of Singapore | 发明人 | Ramanujulu Pondy Murugappan;Yang Tianming;Casey Mei-Wang;Casey Patrick J.;Go Mei Lin |
| 分类号 | C07D471/04;C07D209/14;C07D401/04;C07D403/04 | 主分类号 | C07D471/04 |
| 代理机构 | Schwegman Lundberg & Woessner, P.A. | 代理人 | Schwegman Lundberg & Woessner, P.A. |
| 主权项 | 1. A 1,3,5-substituted indole wherein: the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CH2NR1R2 wherein R1 is H or C1 to C3 alkyl, R1 being optionally substituted with —OH, —SH, —NH2 or NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and R2 is C1 to C3 alkyl or (CH2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group. | ||
| 地址 | Singapore SG | ||