EVOLUTION AND USE OF ENZYMES FOR COMBINATHORIAL AND MEDICINAL CHEMISTRY

摘要

This invention provides libraries of recombinant derivatizing enzymes that a re useful for biocatalytic synthesis of derivatives oforganic molecules, including lead compounds for pharmaceutical use. The recombinant derivatizin g enzymes catalyze reactions such as modification or replacement of functional groups on the organicmolecules, or addition of chemical moieties onto preexisting functional groups. The use of recombinant enzyme libraries enabl es one to obtain enzymes that catalyze the formation of organic molecule derivatives that could not otherwise be made using only naturally occurring enzymes.